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In noted biochemist Jeffrey Bland 's book, " The 2-Day Rejuvenation Diet Program". Silkalike According to him that just one of the first symptoms of chronic poisoning is fatigue. Fatigue with low energy, muscle weakness, intestinal complaints and also the inability to target. Add to that, too much toxins inside your body also bring headaches. Food additives, sugar, alcohol, constipation, caffeine withdrawal, hormonal imbalance, and expertise of known irritants like pollution, perfume and after-shaves can all cause headaches. Another sign that you really need to detoxify.